A device for expression and collection of breast milk includes an actuatable assembly, a breast interface, and a tube. The breast interface is sized to receive a breast and form a fluid tight seal against the breast. The breast interface includes a deformable member disposed within at least a portion of the breast interface. The deformable member deforms in response to actuation of the actuatable assembly and applies vacuum pressure against the breast to express milk. The tube operatively couples the actuatable assembly to the breast interface.