DUBOW, Jordan,BARNHART, Scott David,KOONS, Michael Clinton,HARIHARAN, Madhu Sudan,BILBAULT, Thierry,GIOVINAZZO, Anthony John
申请号：
EP16783684
公开号：
EP3285771A4
申请日:
2016.04.19
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
Methods and pharmaceutical unit dosage forms for treating Parkinson's disease in a subject (e.g., an “off” episode in a subject having Parkinson's disease) are described. The pharmaceutical unit dosage forms are films having a first portion including particles containing an acid addition salt of apomorphine and a second portion containing a pH neutralizing agent. The pharmaceutical unit dosage forms can be flexible and have toughness greater than 100 g×mm. The methods can involve administering to a subject having Parkinson's disease a therapeutic dose sufficient to produce an apomorphine plasma concentrate of at least 2.64 ng/mL within 45 minutes after the administration. The subject may be identified as having low uptake, medium uptake, or high uptake of apomorphine administered via oral mucosa.
