ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
发明人:
RENQUIST, BENJAMIN J.,GEISLER, CAROLINE E.
申请号：
CA3065113
公开号：
CA3065113A1
申请日:
2018.05.25
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
Methods and compositions (such as compounds, drugs, molecules, etc.) forregulating glucose homeostasis, for ex-ample for treating diabetes-related conditions such as hyperinsulinemia andinsulin resistance. The methods and compositions hereinmay feature limiting hepatic mitochondrial uncoupling, decreasing hepatic GABArelease, decreasing hepatic GABA synthesis, and/ormaintaining hepatocyte membrane potential. More specifically, the methods andcompositions herein may feature inhibitors for GABAsynthesis and/or inhibitors for GABA release, e.g., inhibitors for GABA-T,BGT1 (GABA transporter), GAT2 (GABA transporter),M3R, etc. The present invention also features altering food intake byregulating GABA production or GABA release.
