ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
发明人:
Benjamin J. Renquist,Caroline E. Geisler
申请号：
US16617108
公开号：
US20200163908A1
申请日:
2018.05.25
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Methods and compositions (such as compounds, drugs, molecules, etc.) for regulating glucose homeostasis, for example for treating diabetes-related conditions such as hyperinsulinemia and insulin resistance. The methods and compositions herein may feature limiting hepatic mitochondrial uncoupling, decreasing hepatic GABA release, decreasing hepatic GABA synthesis, and/or maintaining hepatocyte membrane potential. More specifically, the methods and compositions herein may feature inhibitors for GABA synthesis and/or inhibitors for GABA release, e.g., inhibitors for GABA-T, BGT1 (GABA transporter), GAT2 (GABA transporter), M3R, etc. The present invention also features altering food intake by regulating GABA production or GABA release.
