CONJUGUE MEDICAMENT-ANTICORPS MODIFIE PAR CYSTEINE ET SON PROCEDE DE PREPARATION

• 收藏
• 分享

专利权人:

SICHUAN BAILI PHARM CO.; LTD.

发明人:

ZHU, YI,WANG, YIXI,ZHUO, SHI,LI, JIE,CHEN, LAN,WAN, WEILI,YU, YONGGUO

申请号：

CA3039559

公开号：

CA3039559A1

申请日:

2017.09.30

申请国别(地区):

CA

年份:

2018

代理人:

摘要：

By inserting cysteine (C) into a heavy chain and light chain of a target antibody, and performing site-specific conjugation through a free thiol group (-SH) of the site-specific inserted cysteine and a linker conjugated with a highly active small molecule cytotoxin, a cysteine modified antibody-drug conjugate with good homogeneity is formed. The insertion sites of cysteine are position 205 and/or position 206 (Kabat numbering) of the light chain of the antibody, and/or position 439 (Kabat numbering) of the heavy chain.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/