SHUTTLEWORTH STEPHEN JOSEPH,CECIL ALEXANDER RICHARD LIAM,HILL THOMAS JAMES,SILVA FRANCK ALEXANDRE
申请号：
NZ59798310
公开号：
NZ597983A
申请日:
2010.08.19
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
597983 Disclosed are compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein: W is O, NH, N(C1-C10 alkyl) or S each X is independently CH or N R1 is a 5 to 7- membered saturated or unsaturated, optionally substituted heterocycle containing at least 1 heteroatom selected from N or O R2 is (LQ)m Y and each R3 is independently H, C1-C10 alkyl, aryl or heteroaryl, are found to be inhibitors of PI3K-p110 delta. Compounds of the disclosure include: 8-Azetidin-1-ylmethyl-2-(1H-indol-4-yl)-4-morpholin-4-ylpyrido[3&rsquo,2&rsquo:4,5]furo[3,2-d]pyrimidine Cyclopropyl-[2-(1H-indol-4-yl)-4-morpholin-4-ylpyrido[3&rsquo,2&rsquo:4,5]furo[3,2-d]pyrimidin-8-ylmethyl]-methyl-amine 3-{ 4-[2-(1H-Indol-4-yl)-4-morpholin-4-yl-pyrido[3&rsquo,2&rsquo:4,5]furo[3,2-d]pyrimidin-8-ylmethyl]-piperazin-1-yl} -propionitrile And 8-(4-Fluoro-piperidin-1-ylmethyl)-2-(1H-indol-4-yl)-4-morpholin-4-yl-pyrido[3&rsquo,2&rsquo:4,5]furo[3,2-d]pyrimidine
