Transplanting the human liver cell to the immunity incomplete liver obstacle non human animal, the non human animal where it produces the chimera non human animal, is obtained the human liver cell which multiplied with this chimera non human animal internal by transplanting to the above-mentioned immunity incomplete liver obstacle non human animal and the similar immunity incomplete liver obstacle non human animal, shows the condition of the human non alcoholic characteristic fat characteristic hepatitis. Transplanting the human liver cell to the immunity incomplete liver obstacle non human animal, the non human animal which is obtained by producing the chimera non human animal, shows the condition of the human fatty liver.免疫不全肝障害非ヒト動物にヒト肝細胞を移植してキメラ非ヒト動物を作製し、このキメラ非ヒト動物体内で増殖したヒト肝細胞を上記の免疫不全肝障害非ヒト動物と同種の免疫不全肝障害非ヒト動物に移植することにより得られ、ヒト非アルコール性脂肪性肝炎の症状を示す非ヒト動物。免疫不全肝障害非ヒト動物にヒト肝細胞を移植してキメラ非ヒト動物を作製することにより得られ、ヒト脂肪肝の症状を示す非ヒト動物。
