PROBLEM TO BE SOLVED: To provide a model animal useful for developing a therapeutic agent of NASH.SOLUTION: There is provided a knockout non-human animal which is deleted whole or part of p62 gene and deleted whole or part of Nrf2 gene, or one part of the knockout non-human animal.COPYRIGHT: (C)2014,JPO&INPIT【課題】NASHの治療剤の開発に有用なモデル動物の提供。【解決手段】p62遺伝子の全部もしくは一部およびNrf2遺伝子の全部もしくは一部が失われたノックアウト非ヒト動物またはその一部。【選択図】なし