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Low pH pharmacological components include antibody structures that trigger lymphocytes
专利权人:
AMGEN RESEARCH (MUNICH) GMBH;AMGEN INC.
发明人:
KANAPURAM, Sekhar,GHATTYVENKATAKRISHNA, Pavan,POMPE, Cornelius,MCAULEY, Arnold,ABEL, Jeff,HUH, Joon,TREUHEIT, Michael,JAGANNATHAN, Bharadwaj
申请号:
PE2019001535
公开号:
PE20200153A1
申请日:
2018.02.02
申请国别(地区):
PE
年份:
2020
代理人:
摘要:
The present invention provides a soluble pharmacological component, including: (a) the construction of an antibody, including a first domain connecting the surface antigen of a target cell, a second domain connecting the second antigen, and a third domain composed of two polypeptide monomers; (b) There is at least one buffer; (c) at least one threshing; (d) at least one surface activity; and the pH value of the pharmacological component is between 3.5 and 6.La presente invencion proporciona una composicion farmaceutica liquida que comprende: (a) una construccion de anticuerpos que comprende un primer dominio que se une a un antigeno de superficie celular diana, un segundo dominio que se une a un segundo antigeno y un tercer dominio que comprende dos monomeros polipeptidicos; (b) al menos un agente amortiguador; (c) al menos un sacarido; y (d) al menos un tensioactivo; y en donde el pH de la composicion farmaceutica esta en el intervalo de 3.5 a 6
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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