LOREY SUSAN,JANOWSKI BERNHARD,PULTKE HEIKO,KATHMANN DANIELA,PARTHIER ANTJE,ANTON ANDREAS
申请号：
NZ62705412
公开号：
NZ627054A
申请日:
2012.12.19
申请国别(地区):
NZ
年份:
2015
代理人:
摘要：
Discloses a proNGF mutant wherein the protease cleavage site R1SK3R4 is substituted at least at positions R1 and K3 corresponding to positions 101 and 103 of the human wildtype proNGF sequence (SEQ ID NO: 1) by any amino acid selected from a non-basic amino acid and Histidine, wherein the sequence is defined as in the complete specification, and related methods of preparing a biologically active human beta-NGF.
