The present invention relates to novel microporous zirconium silicate compositions that are formulated to remove toxins, e.g. potassium ions, from the gastrointestinal tract at an elevated rate without causing undesirable side effects. The preferred composition has at least 95% ZS-9. These compositions are particularly useful in the therapeutic treatment of hyperkalemia. These compositions are also useful in the treatment of chronic kidney disease, coronary vascular disease, diabetes mellitus, and transplant rejection.本發明係關於新穎之微孔矽酸鋯組合物,該組合物經調配而以升高之速率自胃腸道中移除毒素,例如鉀離子,而不引起不良之副作用。較佳之組合物具有至少95%之ZS-9。此組合物尤其可用於治療性處理高鉀血症。此組合物亦可用於治療慢性腎臟疾病、冠狀動脈血管疾病、糖尿病及移植排斥反應。