There is provided have be used as phosphate transport inhibitor, including in gastrointestinal tract and kidney the inhibitor of phosphate cotransporter active NHE3 combine and/or NHE3 regulator, and use what its as therapeutic agent or prophylactic purposes method.提供具有作爲磷酸鹽轉運抑制劑,包括胃腸道和腎臟中磷酸鹽轉運的抑制劑的活性的NHE3結合和/或NHE3調節劑,和用於其作爲治療劑或預防劑的用途的方法。