Disclosed are compositions of matter, treatment methods, and combination therapies for addressing panic attacks in patients suffering from Panic Disorder (PD). In one embodiment the invention provides the use of Noble Gas containing mixtures at a sufficient concentration and frequency to prevent, and/or inhibit frequency of panic attacks. In one particular embodiment xenon gas is administered by inhalation of xenon-oxygen mixtures at concentrations ranging from 15%/85% to 30%/70% with xenon consumption is capped at 3.0 liters per procedure. In other embodiments xenon-oxygen or xenon-oxygen-nitrogen mixtures are administered at sub-anesthetic concentrations which are sufficient to elicit reduction in panic attacks and/or synergize with medications patients are receiving for panic/anxiety symptoms.
