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NEW SUBSTITUTED DIASASPIROPYRIDINE DERIVATIVES APPLIED IN TREATING MCH-1-MEDIATED DISEASES
专利权人:
JANSSEN FARMATSEVTIKA N.V.
发明人:
ANDRES-KhIL' Khose Ignasio (ES),АНДРЕС-ХИЛЬ Хосе Игнасио (ES),AL'KASAR-VAKA Manuehl' Khesus (ES),АЛЬКАСАР-ВАКА Мануэль Хесус (ES),DAUTTsENBERG Frank Mattias (BE),ДАУТЦЕНБЕРГ Франк Маттиас (BE),LINDERS,ANDRES-KHIL KHOSE IGNASIO,ALKASAR-VAKA MANUEHL KHESUS,DAUTTSENBERG FRANK MATTIAS,LINDERS JOANNES TEODORUS
申请号:
RU2009125578/04
公开号:
RU0002461558C2
申请日:
2007.12.04
申请国别(地区):
RU
年份:
2012
代理人:
摘要:
FIELD: medicine, pharmaceutics.SUBSTANCE: present invention refers to aryl- and heteroarylsubstituted diasaspiropyridine derivatives of formula (I) to its pharmaceutically acceptable acid- or base-additive salt wherein A represents a radical of formula (II) wherein each k, l, m, n independently represents an integer equal to 0, 1, 2, 3 or 4, provided (k+1) and (m+n) are equal to 2, 3, 4 or 5; wherein one of -CH2-fragments can be substituted by atom O; and wherein one of -CH2-fragments can be substituted by an oxo group; X represents CH or N; R3 is specified in a group consisting of hydrogen, C1-5alkyl and C3-6cycloalkyl; each R4, R5 is independently specified in a group including hydrogen, halogen, oxo, C1-3alkyl and C1-3alkyloxy; p represents an integer equal to zero, 1, 2 or 3; q represents an integer equal to zero, 1, 2 or 3; each Y1, Y3, is independently specified in a group including a single bond and O; Y2 represents saturated or unsaturated C1-6hydrocarbon radical with a straight chain; B is specified in a group including phenyl optionally substituted by the number of the substitutes R6 each of which is independently specified in halogen; and wherein r represents an integer equal to zero, 1 or 2; alkyl represents a saturated hydrocarbon radical with a straight and branched chain containing said number of carbon atoms; wherein said radical can be optionally substituted by one or more carbon atoms or more radicals specified in a group including halogen, cyano, hydroxy, amino, oxo, carboxyl, nitro, thio and formyl; and halogen represents fluorine, chlorine, bromine or iodine. Also, the invention refers to a pharmaceutical composition based on the compounds of formula I as an active ingredient for preparing a drug for preventing and/or treating mental disorders, including but not limited to anxiety, eating behavior disorder, affective disorders, such as bipolar disorders and depression, psychosis, such as schizophrenia, and sleeping disorders; obesity, diabetes;
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