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包含弱鹼性藥物及有機酸之藥物遞送系統
专利权人:
INC.;APTALIS PHARMATECH
发明人:
VENKATESH, GOPI,LAI, JIN-WANG,VYAS, NEHAL H.,PUROHIT, VIVEK
申请号:
TW98107970
公开号:
TWI440480B
申请日:
2009.03.11
申请国别(地区):
TW
年份:
2014
代理人:
摘要:
The present invention is directed to pharmaceutical compositions, and methods of making such compositions, wherein the compositions comprise a plurality of TPR and RR particles, wherein: the TPR particles each comprise a core coated with a TPR layer; the core comprises a weakly basic, poorly soluble drug and a pharmaceutically acceptable organic acid separated from each other by an SR layer; the RR particles each comprise the weakly basic, poorly soluble drug, and release at least about 80 wt. % of the weakly basic, poorly soluble drug in about 5 minutes when dissolution tested using United States Pharmacopoeia (USP) dissolution methodology (Apparatus 2—paddles@50 RPM and a two-stage dissolution medium at 37° C. (first 2 hours in 0.1N HCl followed by testing in a buffer at pH 6.8).
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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