Gopi Venkatesh;Jin-Wang Lai;Nehal H. Vyas;Vivek Purohit
发明人:
Gopi Venkatesh,Jin-Wang Lai,Nehal H. Vyas,Vivek Purohit
申请号：
US12209285
公开号：
US08133506B2
申请日:
2008.09.12
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention is directed to pharmaceutical compositions, and methods of making such compositions, wherein the compositions comprise a plurality of TPR and RR particles, wherein: the TPR particles each comprise a core coated with a TPR layer； the core comprises a weakly basic, poorly soluble drug and a pharmaceutically acceptable organic acid separated from each other by an SR layer； the RR particles each comprise the weakly basic, poorly soluble drug, and release at least about 80 wt. % of the weakly basic, poorly soluble drug in about 5 minutes when dissolution tested using United States Pharmacopoeia (USP) dissolution methodology (Apparatus 2—paddles@50 RPM and a two-stage dissolution medium at 37° C. (first 2 hours in 0.1N HCl followed by testing in a buffer at pH 6.8).
