Methods of using hedgehog kinase antagonists to inhibit hedgehog signaling and to treat hedgehog mediated disorders

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专利权人:

Curis, Inc.;Genentech, Inc.;Curis; Inc.

发明人:

Evangelista, Marie,De Sauvage, Frederic J.

申请号：

AU2006337085

公开号：

AU2006337085B2

申请日:

2006.12.13

申请国别(地区):

AU

年份:

2013

代理人:

摘要：

The present invention provides for a method of using CDC2L1, CSNK1A1, GYK, NEK1,PLK1, PRKAR1A, PRKRA, TTBK2 or TTK hedgehog kinase antagonists to inhibit hedgehogsignaling, as well as treating and diagnosing disorders relating to hedgehogsignaling or overexpression of hedgehog, including cancer, cell proliferativedisorders, and angiogenesis, neurological disorders, as well as other conditionsaffected by hedgehog signaling such as hair growth, neural stem cell differentiation,chondrogenesis and osteogenesis, lung surfactant production, formation oflamellated bodies in lung cells.

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中国工程科技知识中心

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http://www.ckcest.cn/home/