The Board of Trustees of The Leland Stanford Junior University;University of Washington
发明人:
Garcia, Kenan Christopher,Sockolosky, Jonathan,Baker, David,King, Chris
申请号：
AU2016318621
公开号：
AU2016318621A1
申请日:
2016.09.07
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
Engineered orthogonal cytokine receptor/ligand pairs, and methods of use thereof, are provided. Specifically, the disclosure provides a system for selective activation of a receptor in a cell, the system comprising: (a) an orthogonal receptor, which does not bind to its native ligand； and (b) an orthogonal cytokine, which (i) does not bind to its native receptor and (ii) binds to and activates the orthogonal receptor. Further disclosed are methods of using an engineered cell population for treating disorders.
