THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人:
GARCIA, KENAN CHRISTOPHER,SOCKOLOSKY, JONATHAN,BAKER, DAVID,KING, CHRIS
申请号：
CA2998393
公开号：
CA2998393A1
申请日:
2016.09.07
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
Engineered orthogonal cytokine receptor/ligand pairs, and methods of use thereof, are provided. Specifically, the disclosure provides a system for selective activation of a receptor in a cell, the system comprising: (a) an orthogonal receptor, which does not bind to its native ligand and (b) an orthogonal cytokine, which (i) does not bind to its native receptor and (ii) binds to and activates the orthogonal receptor. Further disclosed are methods of using an engineered cell population for treating disorders.
