Zhengrong Zhou,Anna Norlin-Weissenrieder,Stephanie M. Board
申请号：
US13391878
公开号：
US09820727B2
申请日:
2010.08.20
申请国别(地区):
US
年份:
2017
代理人:
摘要：
A tissue puncture closure device includes a carrier tube and a sealing plug. The carrier tube includes a distal end configured for insertion into the tissue puncture. The sealing plug is positioned in the carrier tube and arranged for ejection from the distal end of the carrier tube into the tissue puncture. The sealing plug includes a first collagen portion having a first cross-linked chemical structure, and a second collagen portion positioned proximal of the first collagen portion in the carrier tube. The second collagen portion has a second cross-linked chemical structure that is different from the first cross-linked chemical structure.
