Александр Васильевич,Олег Дмитриевич,Андрей Александрович,Николай Филиппович,Алёна Александровна
申请号：
EA201800118
公开号：
EA201800118A1
申请日:
2017.06.21
申请国别(地区):
EA
年份:
2018
代理人:
摘要：
the present invention relates to \u0445\u0438\u043c\u0438\u043e\u0442\u0435\u0440\u0430\u043f\u0435\u0432\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u043c agents and their use for the treatment of viral diseases and cancer.these compounds are inhibitors \u043f\u043e\u043b\u0438\u043c\u0435\u0440\u0430\u0437\u044b NS5B hcv dna adp ribose polymerase \u0432\u0433\u0432 and reverse \u0442\u0440\u0430\u043d\u0441\u043a\u0440\u0438\u043f\u0442\u0430\u0437\u044b (rt) of hiv 1 and are intended for the treatment of infection of hepatitis b and c m \u043b\u0435\u043a\u043e\u043f\u0438\u0442\u0430\u044e\u0449\u0438\u0445.these compounds are also of interest as a means for the treatment of cancer.\u0444\u043e\u0441\u0444\u043e\u0440\u0430\u043c\u0438\u0434\u0430\u0442\u043d\u043e\u0435 \u043d\u0443\u043a\u043b\u0435\u043e\u0437\u0438\u0434\u043d\u043e\u0435 \u043f\u0440\u043e\u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u043e general formula 1, its \u0441\u0442\u0435\u0440\u0435\u043e\u0438\u0437\u043e\u043c\u0435\u0440, \u0438\u0437\u043e\u0442\u043e\u043f\u043d\u043e - enriched counterpart, \u0444\u0430\u0440\u043c\u0430\u0446\u0435\u0432\u0442\u0438\u0447\u0435\u0441\u043a\u0438 acceptable salt, hydrate, \u0441\u043e\u043b\u044c\u0432\u0430\u0442 and chris \u0442\u0430\u043b\u043b\u0438\u0447\u0435\u0441\u043a\u0430\u044f or polymorphous formwhere ar represents a \u0430\u0440\u0438\u043b or \u0433\u0435\u0442\u0430\u0440\u0438\u043b r1 represents h or CH3 r2 is a vice, selected from the OCH2CH = CH2, OCH2CH\u2261CH, OCH2CH2CH2OCH3,r3 represents h or CH3 r4 is oh, OR5, NR6R7 r5 is a c1 - c4 - \u0430\u043b\u043a\u0438\u043b r-6 and R7 are not necessarily identical vice.selected from h or CH3 z = o or nh arrow () denotes the position of the deputyr8 and R9 are not necessarily identical alternate selected from h, f, cl, CH3 or so, providedthe solid line and dotted line (accompanying her) together constitute a \u043e\u0434\u0438\u043d\u0430\u0440\u043d\u0443\u044e carbon - carb
