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A PROCESS FOR EFFICIENT CROSS-LINKING OF HYALURONIC ACID
专利权人:
GALDERMA SA
发明人:
Morgan KARLSSON
申请号:
US15747648
公开号:
US20180223053A1
申请日:
2016.07.18
申请国别(地区):
US
年份:
2018
代理人:
摘要:
A process for manufacturing a cross-linked hyaluronic acid (HA) gel product is comprising the steps of: (a) preparing an aqueous mixture of HA and a cross-linking agent selected from multiepoxides and diepoxides; wherein the HA is dissolved in an aqueous solution containing 1-10% (w/w) inorganic hydroxide; and wherein the dissolved HA constitutes more than 10% (w/w) of the final mixture; and (b) subjecting the aqueous mixture to cross-linking conditions to allow the dissolved HA to react with the cross-linking agent so as to obtain a cross-linked HA gel product.
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