And non-insulin-secreting blood glucose lowering drugs, present invention provides a compound of formula, (I) [Each symbol in the formula as described in the specification] Or the compound represented by the formula or a salt thereof (II) [Each symbol in the formula as described in the specification] On pancreatic protection agent comprising a combination of a compound or salt thereof represented by the formula.本発明は、非インスリン分泌型血糖低下薬と、式(I)[式中の各記号は明細書記載のとおり]で表される化合物もしくはその塩または式(II)[式中の各記号は明細書記載のとおり]で表される化合物もしくはその塩とを組み合わせてなる膵保護剤に関する。