THE PRESENT INVENTION RELATES TO AN AGENT FOR PANCREAS PROTECTION WHICH CONTAINS A COMBINATION OF A BLOOD GLUCOSE LOWERING DRUG THAT DOES NOT STIMULATE INSULIN SECRETION AND A COMPOUND REPRESENTED BY THE FORMULA (I) WHEREIN EACH SYMBOL IS DEFINED AS IN THE DESCRIPTION, OR A SALT THEREOF, OR A COMPOUND REPRESENTED BY THE FORMULA (II) WHEREIN EACH SYMBOL IS DEFINED AS IN THE DESCRIPTION, OR A SALT THEREOF.