MOFFAT DAVID FESTUS CHARLES,DAVIES STEPHEN JOHN,CHARLTON MICHAEL HUGH,HIRST SIMON CHRISTOPHER,ONIONS STUART THOMAS,WILLIAMS JONATHAN GARETH
申请号：
IN3041/CHENP/2009
公开号：
IN2009CN03041A
申请日:
2009.05.29
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
Abstract IKK-BETA SERINE-THREONINE PROTEIN KINASE INHIBITORS Compounds of formula (lA) or (IB) are inhibitors of IkB kinase (IKK i activity, and are useful in the treatment of autoimmune and inflammatory- diseases: Formula (A) and (B) wherein R7 is hydrogen or optionally substituted (Cj-C6)alkyl； ring A is an optionally substituted aryl or heteroaryl ring of 5-13 ring atoms； Z is (a) a radical of formula RIR2CHNH-Y-L'-X'-(CH2)Z- wherein； z is 0 or 1； Rl is a carboxylic acid group (-COOH), or an ester group which is hydrolysable by one or more intracellular esterase emzymes to a carboxylic acid group； R2 is the side chain of a natural or non-natural alpha amino acid； Y is a bond, -C(=0), -S(=0)2-, -(p)=0)NR3-, C(+S)-NR3, C(=NH)-NR3 or -S(-0)2NR3- wherein R3 is hydrogen or optionally substituted C1-C6 alkyl； L' is a divalent linker radical of formula -(Alk')m(Q)n(Alk^)p- wherein m, n, p, O, Alk' and Alk" are as defined in the claims.
