David Festus Charles Moffat;Stephane Pintat;Stephen John Davies
发明人:
David Festus Charles Moffat,Stephen John Davies,Stephane Pintat
申请号：
US12867774
公开号：
US08778953B2
申请日:
2009.02.27
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Compounds of formula (I) are p38 MAP kinase inhibitors useful for the treatment of autoimmune and inflammatory diseases: wherein: G is —N═ or —CH═； D is an optionally substituted divalent mono- or bi-cyclic aryl or heteroaryl radical having 5-13 ring members； R6 is hydrogen or optionally substituted CrC3 alkyl； P represents hydrogen and U represents a radical of formula (IA)； or U represents hydrogen and P represents a radical of formula (IA)； wherein A represents an optionally substituted divalent mono- or bicyclic carbocyclic or heterocyclic radical having 5-13 ring members； z is O or 1； —X1-L1-Y— is a linker radical or bond； R1 is a carboxylic acid group (—COOH), or an ester group which is hydrolysable by one or more intracellular esterase enzymes to a carboxylic acid group； and R2 and R3 are as defined in the claims.
