СЕЙДА Агнешка (US),КОЛТЕР Дэвид К. (US),БУЕНСУКЕСО Чарито С. (US),КАЗАНЕКИ Кристиан К. (US),ДХАНАРАДЖ Сридеви (US)
申请号：
RU2014137102
公开号：
RU2014137102A
申请日:
2013.02.14
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. Isolation of the organism is differentiated brown fat-like cells in blood proiskhozhdeniya.2. Brown fat-like cells according to Claim. 1 further characterized by the expression of at least one marker of adipocyte selected from the group consisting of binding protein 4 (aP2) fatty acid receptor α (PPARα), peroxisome proliferator-activated receptor γ (PPARγ), the activated peroxisome proliferator, adiponectin (ADN), uncoupling protein 1 (UCP-1), PR-domain containing protein 16, (PRDM16), PPAR-coactivator-1α (PGC-1α), CCAAT / gene enhancer binding protein β (C / EBPβ), DFFA-like effector a (CIDE-a) and elongation of fatty acids with very long chain, such as protein 3 (ELOVL3) .3. Brown fat-like cells according to claim. 2, in which adipocyte marker may be a brown marker adipocyte selected from the group consisting of disengaging belka1 (UCP-1), PR-domain containing protein 16, (PRDM16), PPAR-coactivator-1α (PGC-1α), CCAAT / binding protein β (C / EBPβ) gene enhancer, DFFA-like a effector (CIDE-a), which stimulates cell death, and the elongation of fatty acids of very long chain, such as protein 3 (ELOVL3 ).4. Brown fat-like cells according to claim. 2, in which the adipogenic marker expressed in brown fat-like cells at higher levels compared to untreated proiskhozhdeniya.5 blood cells. Brown fat-like cells according to Claim. 1 dopolnitelnoharakterizuemye thermogenic potential, which is stimulated by the action of at least one of catecholamines and cyclic AMR.6. Brown fat-like cells according to claim. 1, wherein the blood-derived cells differentiated from the cells of the internal thoracic arterii.7. A pharmaceutical composition comprising a brown fat-like cells according to claim. 2 and pharmaceutically acceptable nositel.8. Cn1. Выделенные, дифференцированные вне организма бурые жироподобные клетки артериального происхождения.2. Бурые жироподобные клетки по п. 1, дополнительно характеризуемые экспрессией по меньшей мере одного маркера адипоцита, выбранного из гру
