Chase Spenser Coffman,Lyndon Fitzgerald Charles, Jr.,Paul Brown,Daniel Benjamin Dadon,Lisa Liu,Cory Robinson,Dale Arlington Thomas, III
申请号：
US16633097
公开号：
US20200253875A1
申请日:
2018.07.25
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The invention provides methods for the preparation of particles including one or more agents, e.g., therapeutic or diagnostic agents. The particles can be formed by creating droplets of a first liquid, e.g., including an agent, and removing the first liquid, e.g., through its dispersal in a second liquid and/or evaporation, to solidify the droplets. Advantageously, the process of forming the particles does not significantly alter the structure or activity of the agents and may enhance the stability of the agents. For example, the particles may be stored for long periods of time without significant loss of activity, and in some embodiments, without the need for refrigeration. These particles may be used to generate stabilized pharmaceutical compositions for storage or other logistical purposes, pharmaceutical suspensions, pharmaceutical powder formulations (e.g., inhalable powders, injectable powders), creams or other topical pastes, nutraceuticals, or cosmetics.
