A bone implant and a manufacturing method thereof are provided. The bone implant is used for implanting a bone of a living body, such as bone, vertebra and alveolar bone. The bone implant includes an implanting body and a plurality of microstructures formed on a surface of the implanting body. An inner layer of the bone implanting body is made of metal including titanium or alloy including titanium, and an outer layer of the bone implanting body is titanium dioxide. Each microstructure has a height and a width, wherein the width is less than 2 micrometer and the height is less than 1 micrometer.本案提出一種骨骼植入物及其製法，骨骼植入物可用於植入活體的骨骼部位，例如骨骼、脊椎或齒槽骨。骨骼植入物包括植體、以及形成於植體表面之數個微結構。植體的材質內層係包含鈦的金屬或合金，外層為二氧化鈦薄膜。各微結構具有一高度及一寬度，寬度小於2微米，而高度小於1微米。
