Pharmaceutical composition for cancer immunotherapy and / or immune activation comprising diaminoheterocyclic carboxamide compound as an active ingredient
The present invention provides a compound useful as an active ingredient of a pharmaceutical composition, for example, a pharmaceutical composition for cancer immunotherapy, and / or a compound useful as an active ingredient of a pharmaceutical composition for immune activation. [MEANS FOR SOLVING PROBLEMS] As a result of intensive studies aimed at creating a pharmaceutical composition for cancer immunotherapy and / or a pharmaceutical composition for immune activation, 6-ethyl-3-({3- Methoxy-4- [4- (4-methylpiperazin-1-yl) piperidin-1-yl] phenyl} amino) -5- (tetrahydro-2H-pyran-4-ylamino) pyrazine-2-carboxamide or pharmaceutics thereof A pharmaceutical composition comprising an immunologically active salt as an active ingredient, wherein the compound or a pharmaceutically acceptable salt thereof is an active ingredient, and / or Alternatively, the present invention has been completed by discovering that it is expected to be used as a pharmaceutical composition for immune activation. [Selection figure] None【課題】医薬組成物、例えばがん免疫治療用医薬組成物の有効成分として有用な化合物、及び／又は、免疫活性化用医薬組成物の有効成分として有用な化合物を提供する。【解決手段】本発明者らは、がん免疫治療用医薬組成物、及び／又は、免疫活性化用医薬組成物の創製を目的に鋭意検討した結果、6-エチル-3-({3-メトキシ-4-[4-(4-メチルピペラジン-1-イル)ピペリジン-1-イル]フェニル}アミノ)-5-(テトラヒドロ-2H-ピラン-4-イルアミノ)ピラジン-2-カルボキサミド又はその製薬学的に許容される塩が優れた免疫活性化作用を有し、当該化合物又はその製薬学的に許容される塩を有効成分とする医薬組成物が、がん免疫治療用医薬組成物、及び／又は、免疫活性化用医薬組成物としての使用が期待されることを知見して本発明を完成した。【選択図】なし
