The invention relates to a prepared derivative (I) of pyridine pyridine,Among them, R1 is h or C1-C4 tar； R2 is - (CH2) n '- B； B is optional C3-C5 or C1-C4 tar, which is replaced by f or C1-C4； n' is 0 or 1-4 integer； and Z, V and W are ch, which is carbon atom, which is replaced by R7； R7 is C1-C4 tar or halogen； R3 and R4 are h or C14 to C4 coke oil； C14 is e, which is an integer, among others. R5 is h or C1-C4 tar； R6 is - (CH2) n-l； n is 0, 1, 2 or 3； L is arilo of six carbon atoms, which is composed of six or six members in different cycles. Heteroatoms are selected from n-u, etc. The most popular compounds are: 2 - {4 - [7-amine-8-ethyl-6 - (1h-imidazol-2-il) - 5-oxo-5, 8-dihydro - [1.8] naftiridin-2-il] - n-piridin-2-il-acetamide,]] - 1 - [1 - [1 - [1 - [1 - [1]]]]]]]] - benzene [1 - [4-cycloacrylonitrile morphine-3-methyl-acetamide, etc. A preparation procedure and a drug synthesis were also mentioned. These compounds inhibit the quinase activity of PDGFs (platelet growth factor) and / or FLT3 (thyroid hormone hormone hormone hormone hormone hormone hormone hormone hormone hormone hormone hormone hormone hormone similar to FMS) receptors, which is an effective means to treat cancer, vascular diseases and other diseases.REFERIDA A UN DERIVADO DE PIRIDINO-PIRIDINONA DE FORMULA (I), DONDE R1 ES H O ALQUILO C1-C4； R2 ES -(CH2)n'-B； B ES CICLOALQUILO C3-C5 O ALQUILO C1-C4 OPCIONALMENTE SUSTITUIDOS CON F O ALCOXI C1-C4； n' ES 0 O UN ENTERO DE 1 A 4； Y, Z, V Y W SON CH, UN ATOMO DE CARBONO SUSTITUIDO CON R7, ENTRE OTROS； R7 ES ALQUILO C1-C4 O HALOGENO； R3 Y R4 SON H, ALQUILO C1-C4, ENTRE OTROS； m E UN ENTERO DE 1 A 4； R5 ES H O ALQUILO C1-C4； R6 ES -(CH2)n-L； n ES 0, 1, 2 O 3； L ES UN ARILO DE 6 ATOMOS DE CARBONO, UN HETEROCICLO DE 6 O 6 MIEMBROS CON UN HETEROATOMO SELECCIONADO DE N U O, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 2-{4-[7-AMINO-8-ETIL-6-(1H-IMIDAZOL-2-IL)-5-OXO-5,8-DIHIDRO-[1,8]NAFTIRIDIN-2-IL]-FENIL}-N-PIRIDIN-2-IL-ACETAMIDA, 2-{6-[7-AMINO-8-ETIL-6-(
