The neuroprotective multifunctional antioxidants are compounds that contain a2-diacetylamino-5-hydroxypyrimidine moiety, having the structural formula:(see above formula)wherein R1 is CH2 or C2H4； R2 is H or -OR4 where R4 is H or aryl； and R3a andR3b areindependently selected from the group consisting of H and -O-alkyl. Theantioxidants areorally bioavailable metal-attenuating multifunctional antioxidants that canindependentlyattenuate transition metals, as well as scavenger free radicals. Themultifunctionalantioxidant compounds, by their ability to independently chelate metals, suchas Fe, Cu orZn, and scavenge free radicals generated from different sources, areneuroprotective and arebeneficial for the treatment of various neurological disorders, such asAlzheimer's disease,Parkinson's disease, ALS, traumatic brain injury, ocular disorders, such ascataract,glaucoma, age-related macular degeneration and other retinal degeneration, aswell as forreducing the progression of diabetic complications.
