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METHODS FOR IMPROVING SEX-DIMORPHIC RESPONSES TO TARGETED THERAPY IN MELANOMA
专利权人:
The University of Texas System;Board of Regents
发明人:
Jennifer WARGO,Timothy P. HEFFERNAN,Swathi ARUR,Miles C. ANDREWS,Joseph MARSZALEK,Christopher VELLANO
申请号:
US16663271
公开号:
US20200164034A1
申请日:
2019.10.24
申请国别(地区):
US
年份:
2020
代理人:
摘要:
Provided herein are methods for the treatment of BRAF-mutant cancer with targeted therapies including androgen receptor (AR) antagonists, G Protein-Coupled Estrogen Receptor 1 (GPER1) agonists, and/or MYC inhibitors. The therapies may be combined with BRAF and MEK-targeted therapy and/or immune checkpoint blockade.
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