As for this invention, it regards the remedy medicine which includes the functional reinforcement T cell and the said functional reinforcement T cell which are obtained Programmed Death 1 of the T cell Ligand 1 (PD L1) and/or Programmed Death 11 igand 2 (PD L2) by the functional reinforcement method and the said functional reinforcement method of the T cell which features that revelation is controlled. This T cell reinforces the immuneresponse for the cancer, effective cancer immunity medical therapy, it is useful in remedy or prevention of the infection disease and the autoimmune disease.本発明は、T細胞のProgrammed Death-1 Ligand 1(PD-L1)及び/又はProgrammed Death-1 1igand 2(PD-L2)の発現を抑制することを特徴とするT細胞の機能増強方法、該機能増強方法により得られる機能増強T細胞及び該機能増強T細胞を含む治療剤に関する。このT細胞は、がんに対する免疫応答を増強し、有効ながん免疫療法、感染疾患や自己免疫疾患の治療又は予防に有用である。
