Pharmaceutical compositions containing a fluoroquinolone antibiotic drug are disclosed. The compositions exhibit improved homogeneity, improved bioavailability, lower turbidity or a combination thereof. The composition can be use as otic or nasal compositions, but are particularly useful as ophthalmic compositions.係揭示一種含有氟喹諾酮抗生素藥物之藥學組成物。該組成物具有經改良之均質性、經改良之生物可獲得性,較低之混濁度,或其組合。該組成物可使用作為耳用或鼻用組成物,但尤佳適用作為眼科用組成物。