KIM, Hyuncheol,김현철,MOON, Hyungwon,문형원,SONG, Tai-Kyong,송태경,CHANG, jin Ho,장진호,YOO, Yang Mo,유양모
申请号：
KRKR2013/008647
公开号：
WO2014/065513A1
申请日:
2013.09.27
申请国别(地区):
WO
年份:
2014
代理人:
摘要：
The present invention relates to an ultrasound contrast medium in which nanoparticles are combined having increased drug delivery capacity and enhanced drug penetration effects, and a preparation method therefor. The ultrasound contrast medium, according to the present invention, comprises drug-loaded nanoparticles combined on the surface thereof, and thus has improved drug delivery capacity and nanoparticle penetration. In addition, the present invention prepares nanoparticles using a cancer target-specific protein, thereby allowing selective diagnosis and treatment of cancer to be simultaneously carried out.La présente invention concerne un milieu de contraste ultrasonore dans lequel des nanoparticules sont combinées, ayant une capacité dadministration de médicament accrue et des effets de pénétration de médicament améliorés, et son procédé de préparation. Le milieu de contraste ultrasonore, selon la présente invention, comprend des nanoparticules chargées de médicament combinées sur la surface de celui-ci, et a ainsi une capacité dadministration de médicament et une pénétration de nanoparticule améliorées. De plus, la présente invention prépare des nanoparticules à laide dune protéine spécifique à une cible de cancer, permettant ainsi la réalisation simultanée dun diagnostic et dun traitement sélectifs dun cancer.본 발명은 약물 수송능력을 증가시키고 약물 침투효과를 높인 나노입자가 결합된 초음파 조영제 및 이의 제조방법에 관한 것이다. 본 발명에 따른 초음파 조영제는 약물을 적재한 나노입자가 표면에 결합되어 있어 약물의 수송능력 및 초음파에 의한 나노입자의 침투능력이 향상되었다. 또한, 본 발명은 암에 대해 표적 지향적 특성을 가지는 단백질을 활용하여 나노입자를 제조함에 따라 암의 선택적 진단 및 치료를 동시에 수행할 수 있다.
