2,3-DIHYDRO-6-NITROIMIDAZO [2,1-B] OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS

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专利权人:

发明人:

HIDETSUGU TSUBOUCHI,KINUE OHGURO,TAKUMI SUMIDA,TAKESHI HASEGAWA,KAZUHO TANAKA,ISAO TAKEMURA,HIROFUMI SASAKI,MOTOHIRO ITOTANI,YOSHIKAZU HARAGUCHI,SHIN MIYAMURA,MAKOTO MATSUMOTO,HIROYUKI HASHIZUME,TATSU

申请号：

MYPI 20044505

公开号：

MY146646A

申请日:

2004.10.30

申请国别(地区):

MY

年份:

2012

代理人:

摘要：

THE PRESENT INVENTION PROVIDES A 2, 3-DIHYDRO-6-NITROIMIDAZO [2,1-B]OXAZOLE COMPOUND REPRESENTED BY THE FOLLOWING GENERAL FORMULA : IN THE ABOVE FORMULA (1), R1 REPRESENTS A HYDROGEN ATOM OR C1-C6 ALKYL GROUP, N REPRESENTS AN INTEGER OF 0 TO 6, R1 AND - (CH2) NR2 MAY FORM A SPIRO RING REPRESENTED BY THE FORMULA (30) BELOW, TOGETHER WITH THE ADJACENT CARBON ATOM (IN THE FORMULA BELOW, RRR REPRESENTS A PIPERIDYL GROUP WHICH MAY HAVE SUBSTITUENTS ON THE PIPERIDINE RING), AND R2 REPRESENTS A BENZOTHIAZOLYLOXY GROUP, QUINOLYLOXY GROUP, PYRIDYLOXY GROUP OR THE LIKE. THE PRESENT COMPOUND HAS AN EXCELLENT BACTERICIDAL ACTION AGAINST MYCOBACTERIUM TUBERCULOSIS, MULTI-DRUG-RESISTANT MYCOBACTERIUM TUBERCULOSIS, AND ATYPICAL ACID-FAST BACTERIA.

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