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2,3-dihydro-6-nitroimidazo (2,1-b) oxazole compounds for the treatment of tuberculosis
专利权人:
Hidetsugu Tsubouchi
发明人:
Hidetsugu Tsubouchi,Hirofumi Sasaki,Motohiro Itotani,Yoshikazu Haraguchi,Shin Miyamura,Makoto Matsumoto,Hiroyuki Hashizume,Tatsuo Tomishige,Masanori Kawasaki,Kinue Ohguro,Takumi Sumida,Takeshi Hasegaw
申请号:
US10574597
公开号:
US08163753B2
申请日:
2004.10.29
申请国别(地区):
US
年份:
2012
代理人:
摘要:
The present invention provides a 2,3-dihydro-6-nitroimidazo[2,1-b]oxazole compound represented by the following general formula: (1) in the above formula (1), R1 represents a hydrogen atom or C1-C6 alkyl group, n represents an integer of 0 to 6, R1 and —(CH2)nR2 may form a spiro ring represented by the formula (30) below, together with the adjacent carbon atom (in the formula below, RRR represents a piperidyl group which may have substituents on the piperidine ring), (30) and R2 represents a benzothiazolyloxy group, quinolyloxy group, pyridyloxy group or the like. The present compound has an excellent bactericidal action against Mycobacterium tuberculosis, multi-drug-resistant Mycobacterium tuberculosis, and atypical acid-fast bacteria.
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