PROBLEM TO BE SOLVED: To provide a high-pressure steam sterilizer in which the shelter density between a door body and an opening can be secured highly, and that can control the occurrence of unexpected steam leak.SOLUTION: The high-pressure steam sterilizer includes: a chamber arranged in the inside of a sterilizer body a door body that opens and shuts the opening of the chamber a lock shaft 60 that synchronizes with the manual displacement operation of the handle installed in the door body and is displaced and a lock shaft holding part 19 including a lock shaft through-hole 19a disposed at the sterilizer body in which the lock shaft 60 penetrates, and further includes a change section in which the relative position of the lock shaft 60 and the lock shaft through-hole 19a is changed based on the shelter density of the chamber lid and the opening.COPYRIGHT: (C)2013,JPO&INPIT【課題】扉体と開口との間の密閉度を高く確保し得て、不測な蒸気漏れの発生を抑制することができる高圧蒸気滅菌器を提供する。【解決手段】滅菌器本体の内部に配置したチャンバーと、チャンバーの開口を開閉する扉体と、扉体に設けられた取手の手動変位操作に連動して変位するロックシャフト60と、滅菌器本体に設けられてロックシャフト60が貫通するロックシャフト貫通孔19aを備えたロックシャフト保持部19と、を備え、ロックシャフト60とロックシャフト貫通孔19aとの相対位置をチャンバ蓋と開口との密閉度を基準として変更する変更部と、を備えている【選択図】図7