ЛИ Пэн,ПЭН Юи,ТОМЕШ Джон,УЭННОДЖЛ Лоренс П.,ЧЖАН Цян
申请号：
RU2014102191
公开号：
RU2014102191A
申请日:
2012.06.22
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. A compound of formula I in which R and R are independently halogen (eg, Cl), —SONH or —COOH, for example, in the para (4-) position, or H (ie, phenyl is unsubstituted)； Y and Z are independently a bond or —CH—； X is N or CR； R, R and R are independently H, phenyl, tolyl or lower (e.g., C) alkyl, e.g. methyl, ethyl or propyl； R is lower alkyl, e.g. , methyl, or R is absent； in free or pharmaceutically acceptable salt form； provided that when R is lower alkyl, soy distinction forms a quaternary ammonium salt, and an associated pharmaceutically acceptable anion is present, for example a halogen ion, for example, chlorine, bromine or iodine ion. 2. The compound according to claim 1, selected from compounds 1-18, Compound 1, Compound 2, Compound 3, Compound 4, Compound 5, Compound 6, Compound 7, Compound 8, Compound 9, Compound 10, Compound 11, Compound 14, Compound 15, Compound 17, Formula 17, Compound 18, Formula 17, Compound 17, Formula 17 or Compound 17. The compound of claim 1, wherein the compound is a compound of Formula II of Formula II wherein R is halogen (e.g., Cl or F), —SONH, or —COOH, in free form or in the form of a pharmaceutically acceptable acid or base addition salt, including a quaternary salt form ammonium, for example methyl halide. 4. A compound of formula III of Formula III in which R and R are independently optionally substituted alkyl, arylalkyl (e.g. benzyl), heteroalkyl, cycloalkyl, cycloalkylalkyl, heteroaryl； in which R, R and R4 are independently H, lower (e.g. C) alkyl, aryl ( n1. Соединение формулы I,в которой Rи Rпредставляют собой независимо галоген (например, Cl), -SONHили -СООН, например, в пара-(4-) положении, или Н (т.е. фенил является незамещенным)；Y и Z представляют собой независимо связь или -СН-；Х представляет собой N или CR；R, Rи Rпредставляют собой независимо Н, фенил, толил или низший (например, С) алкил, например, метил, этил или пропил；Rпредставляет собой низший алкил, например, метил, или Rотсутствует；в свободной форме
