BAKER, STEPHEN RICHARD,BEADLE, CHRISTOPHER DAVID,CLARK, BARRY PETER,MONN, JAMES ALLEN,PRIETO, LOURDES
申请号：
PE0012102014
公开号：
PE16802014A1
申请日:
2013.01.29
申请国别(地区):
PE
年份:
2014
代理人:
摘要：
Refers to compounds of Bicyclo [3.1.0] 4 - substituted hexane of formula (i) wherein R1 and R3 are each h, Benzyl - (2-fluorophenyl) or Methyl R2 is H, aminopropanoilo (2S) - 2 - (2S) - 2 - amino - 4 - (methylsulfanyl butanoil, between others. Preferred compounds are: acid (1S, 2S, 5R, 6S) - 2 - aminospiro [Bicyclo [3.1.0]] - hexane - 4.1 - 2.6 - dicarboxilico cyclopropane acid (1S, 2S, 5R, 6S) - 2 - [[(2S) - 2 - aminopropanoil spiro [] amino] Bicyclo [3.1.0]] - hexane - 4.1 - 2.6 - dicarboxilico cyclopropane among others. It also relates to a Pharmaceutical composition. These compounds are agonists of metabotropic glutamate receptors mglu2 \/ 3 being useful in the treatment of neuropathic pain, Schizophrenia, bipolar disorderSE REFIERE A COMPUESTOS DERIVADOS DE BICICLO[3.1.0]HEXANO 4-SUSTITUIDO DE FORMULA (I) DONDE R1 Y R3 SON CADA UNO H, BENCILO O (2-FLUOROFENIL)METILO R2 ES H, (2S)-2-AMINOPROPANOILO, (2S)-2-AMINO-4-METILSULFANIL-BUTANOIL, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: ACIDO (1S,2S,5R,6S)-2-AMINOESPIRO[BICICLO[3.1.0]HEXANO-4,1-CICLOPROPANO]-2,6-DICARBOXILICO ACIDO (1S,2S,5R,6S)-2-[[(2S)-2-AMINOPROPANOIL]AMINO]ESPIRO[BICICLO[3.1.0]HEXANO-4,1-CICLOPROPANO]-2,6-DICARBOXILICO ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON AGONISTAS DE RECEPTORES DE GLUTAMATO METABOTROPICO MGLU2/3 SIENDO UTILES EN EL TRATAMIENTO DE DOLOR NEUROPATICO, ESQUIZOFRENIA, TRASTORNO BIPOLAR
