Linker toxins and antibody-drug conjugates that bind to human oncology antigen targets such as folate receptor alpha and/or provide anti-tubulin drug activity are disclosed. The linker toxins and antibody-drug conjugates comprise an eribulin drug moiety and can be internalized into target antigen-expressing cells. The disclosure further relates to methods and compositions for use in the treatment of cancer by administering the antibody-drug conjugates provided herein.本發明揭示結合於諸如葉酸受體α之人類腫瘤學抗原標靶及/或提供抗微管蛋白藥物活性之連接子毒素及抗體-藥物結合物。該等連接子毒素及抗體-藥物結合物包含艾日布林藥物部分且可內化至表現標靶抗原之細胞。本發明進一步關於用於治療癌症之方法及組合物，其藉由投與本文提供之抗體-藥物結合物。
