Therapeutic amine-arylsulfonamide conjugate compounds, of the general formula: wherein R&prime is [D-W-], hydroxyl, or alkoxyl R&Prime is independently [D-W&prime-], hydrogen, alkoxy, alkyl, cycloalkyl, alkenyl, alkynyl or aryl, or R&Prime and R&Prime together with the nitrogen atom to which they are attached form a 4-, 5-, 6-, 7- or 8-membered ring optionally containing one or two further heteroatoms independently selected from nitrogen, oxygen and sulfur D is independently a therapeutic amine radical comprising at least one nitrogen atom and optionally at least one oxygen atom coupled to W or W&prime by a nitrogen or oxygen atom W and W&prime are a chemical bond or linker wherein either R&prime is [D-W-] or at least one R&Prime is [D-W&prime-], and pharmaceutically acceptable esters, amides, salts or solvates thereof, pharmaceutical compositions containing same, methods for their preparation, and their use in treating psychiatric, neurologic and metabolic disorders are disclosed.
