WYNNE, GRAHAM MICHAEL,WREN, STEPHEN PAUL,JOHNSON, PETER DAVID,PRICE, PAUL DAMIEN,DE MOOR, OLIVIER,NUGENT, GARY,STORER, RICHARD,PYE, RICHARD JOSEPH,DORGAN, COLIN RICHARD
申请号：
ES07705368
公开号：
ES2522290T3
申请日:
2007.02.09
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
Compound of formula (1), or a pharmaceutically acceptable salt thereof, for use in the treatment or prophylaxis of Duchenne muscular dystrophy or Becker muscular dystrophy, wherein X is O； Y is N； R9 is -L-R3； L is (i) a simple link； or (ii) a linker group selected from: (a) -O-, -S- and - (CO) nNR18-； (b) alkylene, alkenylene and alkynylene, each of which is optionally interrupted by one or more of -O-, -S- or -NR18-, or one or more single, double or triple C-C bond； and (c) a single or double -N-N-bond； in which n is an integer from 0 to 2； and R18 is hydrogen, alkyl or C (O) R16； R3 is alkyl, alkoxy or aryl, each of which is optionally substituted with one to three R2, which may be the same or different； each occurrence of R2 is independently alkyl optionally substituted with one or more of halogen, alkoxy, optionally substituted aryl, optionally substituted thioaryl or optionally substituted aryloxy； optionally substituted alkoxy with optionally substituted alkyl or aryl； hydroxyl； optionally substituted aryl； thioalkyl optionally substituted with optionally substituted alkyl or aryl； thioaryl in which the aryl is optionally substituted； halogen； NO2； CN； OC (>； = W) NR10R11； NR10R11； SO2R12； NR13SO2R14； C (>； = W) R16； NR15C (>； = W) R17； or P (>； = O) OR40R41； W is O, S or NR20； A1, A2, A3 and A4, which may be the same or different, are N or CR1, in which all of A1-A4 are CR1, or one of A1-A4 is nitrogen； each occurrence of R1 is independently (i) hydrogen； or (ii) R2； wherein at least one occurrence of R1 is NR15C (>； = W) R17； NHCONHR15 ', wherein R15' is phenyl, C1-C6 alkyl or CO-phenyl optionally substituted with one or more of halogen； NHSO2- (C1-C6 alkyl)； NHSO2-phenyl； SO2- (C1-C6 alkyl)； or P (>； = O) OR40R41； when in an adjacent pair of A1-A4 each represents CR1, adjacent carbon atoms together with their substituents R1 optionally form a ring B； R10 and R11 are each independently hydrogen, optionally substituted alkyl with optionally subst
