The invention relates to an intraosseous nerve ablation system (50) comprising: a nerve ablation device (10) configured externally of the patient in a configuration that is aligned along a direction into the patient that intersects with or is in close proximity to an intraosseous nerve (100) that innervates a bone (200) in a patient an instrument configured to facilitate positioning of the nerve ablation device (10) at a position along the direction wherein the intraosseous nerve ablation system (50) is configured to position the nerve ablation device (10) at the position and to activate the nerve ablation device (10) at the position to ablate the intraosseous nerve (100). The invention also relates to a method for configuring such intraosseous nerve ablation system (50).