PROBLEM TO BE SOLVED: To provide a new maturing, normalizing or stabilizing agent of a blood vessel or a Tie-2 activating agent.SOLUTION: The maturing, normalizing or stabilizing agent of a blood vessel or the Tie-2 activating agent is composed of an extract derived from plants belonging to the genus Cinnamomum.SELECTED DRAWING: Figure 1【課題】新規な血管の成熟化、正常化もしくは安定化剤、又はTie2活性化剤の提供。【解決手段】本発明はニッケイ(Cinnamomum)属植物由来の抽出物からなる、血管の成熟化、正常化もしくは安定化剤、又はTie2活性化剤を提供する。【選択図】図1