Andrew Geall;Christian Mandl;Manmohan Singh;Derek O'Hagan
发明人:
Andrew Geall,Christian Mandl,Derek O'Hagan,Manmohan Singh,Derek OHagan
申请号：
US13808089
公开号：
US20130195968A1
申请日:
2011.07.06
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Nucleic acid immunisation is achieved by delivering a self-replicating RNA encapsulated within a small particle. The RNA encodes an immunogen of interest, and the particle may deliver this RNA by mimicking the delivery function of a natural RNA virus. Thus the invention provides a non-virion particle for in vivo delivery of RNA to a vertebrate cell, wherein the particle comprises a delivery material encapsulating a self-replicating RNA molecule which encodes an immunogen. These particles are useful as components in pharmaceutical compositions for immunising subjects against various diseases.
