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Virion-like delivery particles for self-replicating RNA molecules
专利权人:
Novartis AG
发明人:
Geall, Andrew,Mandl, Christian,O'Hagan, Derek,Singh, Manmohan,OHagan, Derek
申请号:
AU2011276232
公开号:
AU2011276232B2
申请日:
2011.07.06
申请国别(地区):
AU
年份:
2016
代理人:
摘要:
Nucleic acid immunisation is achieved by delivering a self-replicating RNA encapsulated within a small particle. The RNA encodes an immunogen of interest, and the particle may deliver this RNA by mimicking the delivery function of a natural RNA virus. Thus the invention provides a non- virion particle for in vivo delivery of RNA to a vertebrate cell, wherein the particle comprises a delivery material encapsulating a self-replicating RNA molecule which encodes an immunogen. These particles are useful as components in pharmaceutical compositions for immunising subjects against various diseases.
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