PFIZER INC.;ANNALIESA SYBIL ANDERSON;SUSAN KAY HOISETH;KATHRIN UTE JANSEN;JUSTIN KEITH MORAN;MARK E. RUPPEN
发明人:
ANNALIESA SYBIL ANDERSON,SUSAN KAY HOISETH,KATHRIN UTE JANSEN,JUSTIN KEITH MORAN,MARK E. RUPPEN
申请号：
IL26013518
公开号：
IL260135D0
申请日:
2018.06.19
申请国别(地区):
IL
年份:
2018
代理人:
摘要：
The invention relates to variants of the 2086 lipoprotein from Neisseria meningitidis, also known as ORF2086 or factor H binding protein (fHBP), in particular an isolated polypeptide comprising the amino acid sequence set forth in SEQ ID NO: 76, referred to as variant A05. The invention also relates to immunogenic compositions comprising such polypeptide. Preferred variants have the cysteine at position 1 deleted. The polypeptide may be lipidated.
