BAKER, STEPHEN RICHARD,BEADLE, CHRISTOPHER DAVID,CLARK, BARRY PETER,MONN, JAMES ALLEN,PRIETO, LOURDES
申请号：
PE2014001210
公开号：
PE20141680A1
申请日:
2013.01.29
申请国别(地区):
PE
年份:
2014
代理人:
摘要：
It refers to the compounds in the 4-substitution formula (I) of [3.1.0] UF6 for bicycles, in which R1 and R3 are h, benzene or (2-fluoronil) methyl respectively； R2 is h (2S) - 2-aminoppanoyi (2S) - 2-amino-4-methylsulfanil-butanoil, etc. The most popular compounds are: acid (1s, 2S, 5R, 6S) - 2-amino-helix [bicycle [3.1.0] hexano-4.1 '- cyclopropane] - 2, 6-dioxene； acid (1s, 2S, 5R, 6S) - 2 - [(2S) - 2-amino-aminopropane] amino [bicycle [3.1.0] hexano-4.1' - cyclopropane] - 2, 6-diene； others. He also mentioned a pharmaceutical composer These compounds are enhancers of mglu2 / 3 metabolite glutamate receptor and are useful in the treatment of neuropathy and schizophrenia,Bipolar disorderSE REFIERE A COMPUESTOS DERIVADOS DE BICICLO[3.1.0]HEXANO 4-SUSTITUIDO DE FORMULA (I) DONDE R1 Y R3 SON CADA UNO H, BENCILO O (2-FLUOROFENIL)METILO； R2 ES H, (2S)-2-AMINOPROPANOILO, (2S)-2-AMINO-4-METILSULFANIL-BUTANOIL, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: ACIDO (1S,2S,5R,6S)-2-AMINOESPIRO[BICICLO[3.1.0]HEXANO-4,1'-CICLOPROPANO]-2,6-DICARBOXILICO； ACIDO (1S,2S,5R,6S)-2-[[(2S)-2-AMINOPROPANOIL]AMINO]ESPIRO[BICICLO[3.1.0]HEXANO-4,1'-CICLOPROPANO]-2,6-DICARBOXILICO； ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON AGONISTAS DE RECEPTORES DE GLUTAMATO METABOTROPICO MGLU2/3 SIENDO UTILES EN EL TRATAMIENTO DE DOLOR NEUROPATICO, ESQUIZOFRENIA, TRASTORNO BIPOLAR
